Listen to Coronavirus Patient Zero
Poor Principal Walter Russ. He's "desperate" for designer Florence Waters to renovate the school's disgusting basement bathrooms, and the stress is causing him to get, "ahem, " all clogged up. Luckily, during their stressful summer-school internships, the sixth graders discover the perfect way for everyone to relax: by enjoying an ancient Roman spa and bath buried in the school's basement " Includes a classroom activity."
This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches.A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes.
" There's A Monkey In My Bathroom" is a delightful story about a monkey that barged his